SPLICING REPORTER MICE REVEALED THE EVOLUTIONALLY CONSERVED SWITCHING MECHANISM OF TISSUE-SPECIFIC ALTERNATIVE EXON SELECTION.

Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection.

Since alternative splicing of pre-mRNAs is essential for generating tissue-specific diversity in proteome, elucidating its regulatory mechanism is indispensable to understand developmental process or tissue-specific functions.We have been focusing on tissue-specific regulation of mutually exclusive selection of alternative exons because this implie

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Correlative vs. Causative Relationship between Neonatal Cranial Head Shape Anomalies and Early Developmental Delays

Deformational plagiocephaly and craniosynostosis are two AGE-DEFYING DAY CREME of the most common neonatal cranial head shape anomalies.Traditionally, both entities were thought to cause aesthetic concerns solely.Recently, many groups have demonstrated that both conditions are strongly associated with developmental delays.The relationship between t

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Tissue-Specific Human Extracellular Matrix Scaffolds Promote Pancreatic Tumour Progression and Chemotherapy Resistance

Over 80% of patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed Bread Knives at a late stage and are locally advanced or with concurrent metastases.The aggressive phenotype and relative chemo- and radiotherapeutic resistance of PDAC is thought to be mediated largely by its prominent stroma, which is supported by an extracellular mat

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Data Collection Framework for Energy Efficient Privacy Preservation in Wireless Sensor Networks Having Many-to-Many Structures

Wireless sensor networks (WSNs) generally have a many-to-one structure so that event information flows from sensors to a unique sink.In recent WSN applications, many-to-many structures evolved due to the need for conveying collected event information to multiple sinks.Privacy preserved data collection models in the literature do not solve the probl

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